User Contributed Dictionary
Noun
Extensive Definition
Sulfatases are esterase enzymes which remove sulfate from a variety of
substrates by hydrolyzing various sulfate
esters.
The following sulfatases were shown to be
structurally related based on their sequence
homology:
- cerebroside-sulfatase
- steryl-sulfatase
- arylsulfatase A (ASA), a lysosomal enzyme which hydrolyzes cerebroside sulfate;
- arylsulfatase B (ASB) which hydrolyzes the sulfate ester group from N-acetylgalactosamine 4-sulfate residues of dermatan sulfate;
- arylsulfatase C (ASD) and E (ASE); steryl-sulfatase (STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy steroid sulfates;
- iduronate 2-sulfatase (IDS), a lysosomal enzyme that hydrolyzes the 2-sulfate groups from iduronic acids in dermatan sulfate and heparan sulfate;
- N-acetylgalactosamine-6-sulfatase , which hydrolyzes the 6-sulfate groups of the N-acetyl-D-galactosamine of chondroitin sulfate and D-galactose 6-sulfate units of keratan sulfate;
- N-sulfoglucosamine sulfohydrolase , the lysosomal enzyme that hydrolyses N-sulfo-D-glucosamine into glucosamine and sulfate;
- glucosamine-6-sulfatase (G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate;
- N-sulfoglucosamine sulfohydrolase , the lysosomal enzyme that hydrolyses N-sulfo-D-glucosamine into glucosamine and sulfate;
- sea urchin embryo arylsulfatase ;
- green algae arylsulfatase , which plays a role in the mineralization of sulfates; and
- arylsulfatase from Escherichia coli, Klebsiella aerogenes and Pseudomonas aeruginosa.